原发性纵隔大B细胞淋巴瘤 (Primary mediastinal large B-cell lymphoma)
原发性纵隔大B细胞淋巴瘤是一种起源于胸腺髓质B细胞的侵袭性非霍奇金淋巴瘤，好发于年轻女性。其发病机制与JAK-STAT及NF-κB信号通路异常激活有关，肿瘤细胞常表达CD20、CD30，并呈现特征性基因表达谱。临床上患者多以快速增大的前纵隔巨大肿块起病，可压迫上腔静脉、气道或心包，引起咳嗽、呼吸困难、颈部肿胀及上腔静脉综合征。诊断依赖影像学与活检病理，需与弥漫大B细胞淋巴瘤、霍奇金淋巴瘤鉴别。治疗以R-CHOP方案联合利妥昔单抗的免疫化疗为主，难治复发者可考虑CAR-T细胞治疗或造血干细胞移植，预后相对较好。
获取 原发性纵隔大B细胞淋巴瘤 专属定制方案 共 8 个数据集
表格Frequent occurrence of deletions in primary mediastinal B-cell lymphoma
PMBCL频发缺失数据集
Frequent occurrence of deletions in primary mediastinal B-cell lymphomaPMBCL拷贝数缺失分析数据
表格Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL ATAC-seq
PMBCL IRF4突变ATAC-seq数据集
Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL ATAC-seqPMBCL IRF4突变ATAC-seq数据
表格Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL ChIP-seq
PMBCL IRF4突变ChIP-seq数据集
Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL ChIP-seqPMBCL IRF4突变ChIP-seq数据
表格Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL RNA-seq
PMBCL IRF4突变RNA-seq数据集
Somatic IRF4 mutations drive disease-defining expression signatures and thymic tropism in PMBCL RNA-seqPMBCL IRF4突变RNA-seq数据
表格Expression data from Diffuse Large B Cell Lymphoma patients
DLBCL患者基因表达数据集
Expression data from Diffuse Large B Cell Lymphoma patients含PMBL标签的DLBCL表达谱
表格Molecular subtypes of DLBCL have distinct chromosomal aberrations
DLBCL分子亚型表达与拷贝数数据集
Molecular subtypes of DLBCL have distinct chromosomal aberrations含PMBL亚型的DLBCL表达数据
表格Whole Exome Sequencing of Primary Mediastinal B-cell Lymphoma
PMBCL全外显子测序数据集
Whole Exome Sequencing of Primary Mediastinal B-cell LymphomaPMBCL外显子与靶向测序数据
表格Whole-genome sequencing of primary mediastinal large B-cell lymphoma
PMBCL全基因组测序数据集
Whole-genome sequencing of primary mediastinal large B-cell lymphomaPMBCL全基因组测序数据