多发性内分泌腺瘤病 1 型 (Multiple endocrine neoplasia, type 1 (MEN 1))
多发性内分泌腺瘤病 1 型是一种常染色体显性遗传的肿瘤综合征,由 MEN1 基因突变引起,主要累及甲状旁腺、胰腺内分泌腺和垂体前叶。典型表现为原发性甲状旁腺功能亢进、胃肠胰神经内分泌肿瘤和垂体腺瘤,其中甲状旁腺功能亢进最为常见。诊断依赖临床标准、内分泌激素测定及基因检测。治疗以手术切除肿瘤为主,需多学科协作,重点进行定期筛查与长期随访。该病是研究神经内分泌肿瘤发生机制和遗传咨询的重要模型。
获取 多发性内分泌腺瘤病 1 型 专属定制方案 共 10 个数据集
文本GSE65529: Long non-coding RNA expression profiling of sporadic and hereditary (MEN1) pancreatic endocrine tumors
GSE65529:散发性及遗传性(MEN1)胰腺内分泌肿瘤长链非编码RNA表达谱
GSE65529: Long non-coding RNA expression profiling of sporadic and hereditary (MEN1) pancreatic endocrine tumorsMEN1遗传性胰腺肿瘤lncRNA数据集
图像Digital Pathology Images of Neuroendocrine Tumors in MEN1 patients
Zenodo-MEN1-NETs:MEN1相关神经内分泌肿瘤免疫组化数字病理图像集
Digital Pathology Images of Neuroendocrine Tumors in MEN1 patientsMEN1神经内分泌肿瘤数字病理图像集
文本GSE115456: DNA methylation profiling of MEN1-associated bronchial carcinoids
GSE115456:1型多发性内分泌腺瘤病相关支气管类癌的DNA甲基化数据集
GSE115456: DNA methylation profiling of MEN1-associated bronchial carcinoidsMEN1相关支气管类癌甲基化芯片数据集
表格ClinVar MEN1 Variation and Phenotype Database
ClinVar MEN1基因临床变异表型数据库
ClinVar MEN1 Variation and Phenotype DatabaseMEN1基因变异与临床表型分类数据库
多模态The Cancer Genome Atlas Pancreatic Neuroendocrine Tumors (TCGA-PANET)
TCGA-PANET:癌症基因组图谱胰腺神经内分泌肿瘤数据集(包含MEN1突变亚型)
The Cancer Genome Atlas Pancreatic Neuroendocrine Tumors (TCGA-PANET)包含MEN1突变的胰腺神经内分泌肿瘤多模态数据集
文本GSE153164: Single-cell transcriptomic dynamics of pancreatic islets in a Men1-knockout mouse model
GSE153164:MEN1敲除小鼠模型的胰岛单细胞转录组动力学研究
GSE153164: Single-cell transcriptomic dynamics of pancreatic islets in a Men1-knockout mouse modelMen1敲除小鼠胰岛单细胞转录组数据集
文本GSE97354: Genome-wide expression analysis of MEN1-associated anterior pituitary adenomas
GSE97354:MEN1相关的垂体前叶腺瘤全基因组表达分析
GSE97354: Genome-wide expression analysis of MEN1-associated anterior pituitary adenomasMEN1相关垂体前叶腺瘤基因表达数据集
文本GSE117904: Gene expression profile of duodenal gastrinomas in multiple endocrine neoplasia type 1
GSE117904:1型多发性内分泌腺瘤病关联十二指肠胃泌素瘤基因芯片数据集
GSE117904: Gene expression profile of duodenal gastrinomas in multiple endocrine neoplasia type 1MEN1十二指肠胃泌素瘤基因芯片数据集
文本GSE129486: Transcriptomic profiling of MEN1 and non-MEN1 pancreatic neuroendocrine tumors
GSE129486:MEN1与非MEN1胰腺神经内分泌肿瘤转录组剖析
GSE129486: Transcriptomic profiling of MEN1 and non-MEN1 pancreatic neuroendocrine tumorsMEN1型胰腺神经内分泌肿瘤转录组数据集
文本GSE162489: Single-cell RNA sequencing of parathyroid tumors in multiple endocrine neoplasia type 1
GSE162489:1型多发性内分泌腺瘤病副甲状腺腺瘤的单细胞RNA测序数据集
GSE162489: Single-cell RNA sequencing of parathyroid tumors in multiple endocrine neoplasia type 1MEN1患者副甲状腺肿瘤单细胞转录组数据集